Development on a third Deadpool film began at 20th Century Fox by November 2016. David Leitch was hired to direct Deadpool 2 in November 2016 after Tim Miller chose not to return due to creative differences with star Ryan Reynolds.
Levy was revealed to be directing the film in March 2022. Jackman decided to reprise his role as Wolverine from Fox's X-Men film series in August 2022. This decision solved the creative team's issues with settling on a story.
Wade Wilson uses Cable's time-travel device to prevent the death of his girlfriend Vanessa Carlysle in 2018. He then travels from his universe Earth-10005 to Earth-616 hoping to join that reality's Avengers but is rejected and returns to his own universe before being detained by the Time Variance Authority six years later.
Deadpool and Wolverine grossed $636.7 million in the United States and Canada and $701.3 million in other territories for a worldwide total of $1.338 billion. It became the fifth-highest-grossing MCU film and the 20th-highest-grossing film of all time during its release.
Emma Corrin joined the cast in a lead villain role playing Cassandra Nova. Matthew Macfadyen appeared as Mr Paradox an agent of the Time Variance Authority while Corrin was filmed hiding their arm so it could be replaced with a digital arm that interacts with a digital double of the other actor.