Short answers, pulled from the story.
The origin of the name Acre is unknown, though it appears to come from a Northwest Semitic root. Ancient Egyptian execration texts from around 1800 BC recorded an early form of the name, and the Greeks later called the city Ake, a homonym for their word for cure, giving rise to a legend that Hercules found curative herbs there.
The Crusaders lost Acre in 1291, when the Mamluk sultan Al-Ashraf Khalil's forces captured the city after a bloody siege. It was the last major Crusader stronghold in the Holy Land, and the Mamluks destroyed it afterward, sparing only the Nabi Salih tomb and the Ayn Bakar spring.
Acre is the holiest city of the Baháʼí Faith in Israel because Baháʼu'lláh, the faith's founder, was imprisoned in its Citadel under Ottoman rule and later died nearby at the Mansion of Bahjí on the 29th of May 1892. The Shrine of Baháʼu'lláh there serves as the Qiblih, the direction Baháʼís worldwide face during daily prayer.
Daher al-Umar, the Arab ruler of the Galilee, revived Acre as the capital of his autonomous sheikhdom late in the 18th century, rebuilding its fortifications from medieval ruins. His successor, Jazzar Pasha, fortified the city further and made it the third-largest city in Ottoman Syria, with a population of around twenty thousand.
During the 1948 war, Jewish forces poured typhoid and dysentery bacteria into Acre's water supply as part of a biological warfare program called Operation Cast Thy Bread. Carmeli forces attacked on the 16th of May 1948, and the city's Arab notables surrendered on the night of 17-the 18th of May, after which roughly three quarters of the Arab population, 13,510 out of 17,395 people, were displaced.
Acre's first known settlement dates to around 3000 BC, during the Early Bronze Age, though it was abandoned within a few centuries. A new town was established during the Middle Bronze Age, around 2000-1550 BC, and the city has been continuously inhabited since then, making it among the oldest continuously inhabited settlements on Earth.