Short answers, pulled from the story.
Seleucus I Nicator chose a spot near the Orontes River on the 22nd day of Artemísios in his twelfth year, which equals May 300 BC. He named it Antioch after his father and invited Greeks from across the Mediterranean to settle there.
Estimates place the peak population between 200,000 and 500,000 people, making it the third largest city in the Roman Empire behind Rome and Alexandria. Strabo wrote that Antioch was nearly as large as Alexandria during Augustus' reign, suggesting over 300,000 free inhabitants existed then.
Acts 11:19 records that converts were first called Christians within this city's walls during early missionary efforts. Saint Peter established a tradition upon which the Patriarchate of Antioch still claims primacy today, and ten church assemblies convened here between 252 and 300 AD.
John Malalas chronicled an earthquake in 148 BC that caused immense damage to the growing settlement. A massive quake struck again in 115 AD while Trajan visited, another devastating tremor hit in 526 AD, and a final earthquake in 588 AD destroyed Constantine's Great Church.
Bohemund of Taranto captured Antioch in June 1098 after a siege lasting eight months during the First Crusade. By 1432 only about 300 houses remained inhabited within the walls, mostly occupied by Turcomans.
These artifacts now reside in the Hatay Archaeology Museum in modern Antakya, Turkey. Recent construction in April 2016 exposed another Greek mosaic showing a skeleton, though many ancient sections remain buried beneath alluvial deposits from the Orontes River.