Short answers, pulled from the story.
The year 1913 marked the official merger of two distinct towns into one entity known as Winston-Salem. A referendum led to their official incorporation as a single city in 1913 after decades of existing side by side.
Bishop August Gottlieb Spangenberg selected a site for Moravian settlers in 1753 to establish the town of Salem. The first tree was felled for the building of Salem on the 6th of January 1766 marking the beginning of this unique religious settlement.
R.J. Reynolds founded his tobacco company in 1875 and later introduced Camel cigarettes in 1913. By the 1940s sixty percent of Winston-Salem workers employed themselves either at Reynolds or within Hanes textile factories making the city an official port of entry despite its inland location.
Winston-Salem State University evolved from Slater Industrial Academy founded by Simon Green Atkins in 1892 while Wake Forest College relocated to the area in 1956 transforming into Wake Forest University. Salem Academy has provided education to young women since 1772 making it the oldest continuously operating educational institution for women in America.
Public and private investment totaling seven hundred thirteen million dollars created the Wake Forest Innovation Quarter which anchors the east end of downtown Winston-Salem under governance by the Wake Forest School of Medicine. Ninety companies operate within its boundaries employing over three thousand six hundred workers to drive economic development through programs designed for tenants and residents seeking new ideas.