Short answers, pulled from the story.
Play begins when the first player serves by asking a question and each participant continues the conversation using only questions for as long as possible. No declarative statements are allowed during the exchange and hesitations, statements, or non sequiturs result in a foul immediately.
When a foul happens, the opponent receives one point automatically and the first person to reach three points wins a single game. Matches typically go best out of three games to determine the overall winner.
Tom Stoppard featured Questions prominently in his play Rosencrantz and Guildenstern Are Dead and an abridged form appeared in the 1990 film adaptation of that same work. The dialogue between characters demonstrates how the game explores existential themes while players must maintain a continuous exchange without breaking character.
The neo-Vaudevillian troupe The Flying Karamazov Brothers incorporated Stoppard's version into at least two shows named Juggling and Cheap Theatrics and Club! Ivan and Dmitri performed while juggling three beanbags simultaneously and Howard Jay Patterson and Paul David Magid played the game during these acts.
A variation appeared on the show Whose Line Is It Anyway? where Players get replaced when they foul under the host's direction and rules for determining fouls are not so strict in this version. Statements count as fouls but non-sequiturs rarely do in this format and the host arbitrarily chooses a winner regardless of actual performance.