Short answers, pulled from the story.
George Rogers Clark established a settlement on Corn Island in 1778, marking the birth of what would become Louisville. The Virginia General Assembly approved the town charter named after King Louis XVI of France by 1780.
Protestant mobs attacked German and Irish Catholic neighborhoods during election day events known as Bloody Monday resulting in 22 deaths and widespread property damage before the Civil War even began.
Heavy rainfall caused the Ohio River to crest at record levels above flood stage throughout January 1937 submerging 60 to 70 percent of the city and forcing evacuation of 175,000 residents. Ninety people died during the disaster which lasted into early February and caused complete power loss for four days.
About one-third of all bourbon whiskey comes from Louisville with Brown-Forman headquarters located there. Heaven Hill operates its current primary distillery site called Bernheim near Brown-Forman's facility.
Since the 6th of January 2003 Louisville merged its government with Jefferson County forming coterminous borders as second such merger in state history. The consolidated area had a total population of 782,969 according to the 2020 census.