Short answers, pulled from the story.
Lady Macbeth walks through the castle in her sleep while scrubbing invisible blood from her hands. Her death follows this scene and inspires Macbeth to deliver his famous Tomorrow and tomorrow and tomorrow speech.
Stephanie Chamberlain argues that Lady Macbeth wants power but her power is conditioned on maternity. This status was conflicted in early modern England where mothers were often accused of hurting people placed in their hands.
Sarah Siddons, Charlotte Melmoth, Helen Faucit, Ellen Terry, Jeanette Nolan, Vivien Leigh, Isuzu Yamada, Simone Signoret, Vivien Merchant, Glenda Jackson, Francesca Annis, Judith Anderson, Judi Dench, Renee O'Connor, Helen McCrory, Keeley Hawes, Alex Kingston, Reshmi Sen, Marion Cotillard, Hannah Taylor-Gordon, Frances McDormand, Tabu, Ruth Negga, Saoirse Ronan, and Valene Kane have all played this role over centuries.
Frances McDormand appeared as Lady Macbeth in the 2021 film The Tragedy of Macbeth directed by Joel Coen who was making his first film without brother Ethan Coen. She acted opposite Denzel Washington playing Macbeth.
Daniel Wattenberg wrote an August 1992 article titled The Lady Macbeth of Little Rock comparing Hillary Clinton to Shakespeare's famous character.