Short answers, pulled from the story.
Edward VI was born on the 12th of October 1537 at Hampton Court Palace. He became King of England and Ireland on the 28th of January 1547, at the age of nine, and was crowned at Westminster Abbey on the 20th of February 1547.
England was governed by a regency council throughout Edward's reign because he never reached adulthood. From 1547 to 1549, his uncle Edward Seymour, Duke of Somerset, served as Lord Protector. John Dudley, Duke of Northumberland, led the council from 1550 until Edward's death in 1553.
The first Book of Common Prayer was introduced in 1549, followed by a revised version in 1552. The Ordinal of 1550 replaced the Catholic ordination of priests with a government-run appointment system. Cranmer's Forty-two Articles were prepared to define reformed doctrine. These changes effectively abolished the Latin Mass and established Protestantism as the religion of England.
Edward excluded both half-sisters on the grounds that they had been declared illegitimate under Henry VIII and had never been formally made legitimate again. He also opposed Mary on religious grounds, fearing her Catholic faith would reverse the Protestant reforms of his reign. He named Lady Jane Grey as his heir in his "Devise for the Succession."
Edward VI died on the 6th of July 1553 at Greenwich Palace, aged fifteen. The Venetian ambassador Giacomo Soranzo reported that he died of consumption, which historians generally interpret as tuberculosis. Some historians suggest he contracted tuberculosis after a bout of measles and smallpox in 1552, while others believe his symptoms pointed to acute bronchopneumonia leading to a lung abscess and kidney failure.
Lady Jane Grey reigned for nine days. She was proclaimed queen on the 10th of July 1553 and was deposed on the 19th of July when the Privy Council publicly proclaimed Mary as queen. Jane was later executed on the 12th of February 1554, following her father's involvement in Wyatt's rebellion.