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— CH. 1 · THE GRAIN SHIPS ARRIVE —

Plague of Justinian

~4 min read · Ch. 1 of 6
6 sections

  • In 541, grain ships arrived at the port of Pelusium near Suez in Egypt. These vessels carried infected rats and fleas that would soon carry Yersinia pestis into the heart of the Byzantine Empire. The plague spread from this Egyptian entry point to Constantinople by 542. Procopius recorded the outbreak starting in 541 from that specific port. By 543, the disease had reached every corner of Justinian's empire. It persisted in Northern Europe and the Arabian Peninsula until 549. The contagion moved around the Mediterranean Sea until 544. Roman Egypt served as a significant source for these rodents. Fleas potentially affected by y. pestis were already a known pest control issue there. The Romans imported large amounts of grain from Egypt during this period.

  • Procopius wrote that the plague killed 10,000 people daily at its peak in Constantinople. He described bodies stacked in the open because there was no room to bury them. Funeral rites went unattended while the entire city smelled like death. John of Ephesus provided another first-hand account of the ravages. Evagrius Scholasticus survived the buboes but lost his wife, daughter, and most servants. He later became a church historian after losing many family members. Procopius noted sufferers experienced delusions, nightmares, fevers, and swellings behind the ears. Some victims fell into coma or died despite treatments. People tried cold baths, powders blessed by saints, and magic amulets when drugs failed. Hospitals received those who could not quarantine themselves effectively.

  • Researchers confirmed in 2013 that Yersinia pestis caused the Justinian plague. Ancient DNA samples linked the pathogen to strains found in the Tian Shan mountain ranges. These mountains sit on the borders of Kyrgyzstan, Kazakhstan, and China. A skeleton dated around 180 AD from Tian Shan contained DNA closely related to the Justinian strain. This suggests nomadic peoples like the Xiongnu spread the disease across the Eurasian steppe. Modern strains currently found in Tian Shan are the most basal known compared to the Justinian strain. Genetic studies indicate the origin was likely Central Asia rather than sub-Saharan Africa. The Black Death does not appear to be a direct descendant of this specific strain. However, the spread may have caused evolutionary radiation leading to extant clades today.

  • Some scholars assert the plague killed up to 40% of Constantinople's inhabitants at its height. Estimates suggest it caused deaths for up to a quarter of the Eastern Mediterranean population. Other researchers argue these figures are exaggerated by primary sources. Lee Mordechai and Merle Eisenberg claim the plague did not cause widespread demographic decline. They suggest mortality might have been high locally but had minor long-term effects. Peter Sarris criticizes their methodology regarding source handling and genetic evidence. Haggai Olshanetsky and Lev Cosijns reassert that archaeological evidence shows no economic or demographic decline in the 6th century Eastern Mediterranean. Research published in 2019 argued the death toll has been exaggerated when comparing it to modern pandemics. Eyewitness accounts describing hysterical tones may mislead historical interpretation.

  • Justinian demanded annual taxes even from farmers who died during the epidemic. He collected amounts for deceased neighbors as well as living individuals. This ruthless response left rural freeholders with no mercy despite the devastation. Grain prices rose in Constantinople because farmers could not tend crops. The empire struggled to fund wars against Vandals in Carthage and Ostrogoths in Italy. Huge money was spent on great churches like Hagia Sophia while tax revenues declined. New legislation addressed inheritance suits brought by victims dying intestate. The plague weakened Byzantine armies at a critical moment. Justinian's forces nearly retaken all of Italy before the Lombards invaded Northern Italy in 568. The small army left behind was defeated, establishing the Kingdom of the Lombards.

  • Archaeological findings from Greek-language epitaphs support dating the first outbreak to 541 CE. Nancy Benovitz identified a spike in Christian epitaphs around Gaza and the Negev in the 540s. Skeletons from Aschheim in Upper Bavaria dated to the 6th century contained Yersinia pestis DNA. Research published in 2024 linked major plagues to cooler and drier climate conditions. Colder weather may have contributed to disease spread during these periods. Climate stress interacted with food availability and rodent populations making people more susceptible. Social variables combined with biological factors to increase vulnerability. Epitaph data alongside skeletal findings provide physical evidence for historical claims. These materials help verify traditional dating against revisionist arguments about impact.

Common questions

When did the Plague of Justinian start and end?

The outbreak began in 541 and persisted until 549. The disease spread from Egypt to Constantinople by 542 and reached Northern Europe and the Arabian Peninsula before ending.

Where did the Plague of Justinian originate according to genetic studies?

Genetic research indicates the pathogen originated in Central Asia near the Tian Shan mountain ranges. Ancient DNA samples link the strain to nomadic peoples like the Xiongnu who traveled across the Eurasian steppe.

How many people died during the peak of the Plague of Justinian in Constantinople?

Procopius recorded that the plague killed 10,000 people daily at its height in Constantinople. Some scholars estimate up to 40% of the city's inhabitants perished while other researchers argue these figures are exaggerated.

What economic impact did the Plague of Justinian have on the Byzantine Empire?

Justinian demanded annual taxes even from farmers who died during the epidemic causing severe financial strain. Grain prices rose because farmers could not tend crops while tax revenues declined despite huge spending on churches.

Did the Plague of Justinian cause widespread demographic decline in the Eastern Mediterranean?

Some researchers claim mortality was high locally but had minor long-term effects on population numbers. Archaeological evidence suggests no significant economic or demographic decline occurred in the 6th century Eastern Mediterranean.

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All sources

43 references cited across the entry

  1. 1citationPlague, Justinianic (Early Medieval Pandemic)Dionysios Stathakopoulos — Oxford University Press — 2018
  2. 2citationplague and epidemicsJon Arrizabalaga — Oxford University Press — 2010
  3. 3bookStudies in the History of Medicine in IranWillem Floor — Mazda Publishers — 2018
  4. 4journalThe Justianic Plague: The economic consequences of the pandemic in the Eastern Roman empire and its cultural and religious effectsMischa Meier — August 2016
  5. 5journalNew Approaches to the 'Plague of Justinian'.Peter Sarris — 2022
  6. 6journal"The Justinianic Plague": The Effects of a Pandemic in Late Antiquity and the Early Middle Ages.Gabriel-Viorel Gârdan — 2020
  7. 7journalRejecting Catastrophe: The Case of the Justinianic PlagueLee Mordechai et al. — 2019
  8. 8journalViewpoint New Approaches to the 'Plague of Justinian'Peter Sarris — Oxford University Press — November 13, 2021
  9. 9journalThe epidemic of Justinian (AD 542: a prelude to the Middle Ages.F. P. Retief et al. — 2005
  10. 10webModern lab reaches across the ages to resolve plague DNA debateMay 20, 2013
  11. 11journalYersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of KyrgyzstanGalina A. Eroshenko — October 26, 2017
  12. 12journal137 ancient human genomes from across the Eurasian steppesPeter de B. Damgaard — May 9, 2018
  13. 13journalThe Justinianic plague: origins and effectsPeter Sarris — August 2002
  14. 14inlineJohn of Ephesus, Ecclesiastical History, part 2. Translation of relevant portions here.
  15. 15newsEurope's Plagues Came From China, Study FindsNicholas Wade — October 31, 2010
  16. 16journalNetworks of Rome, Byzantium, and ChinaMurray Eiland — 2022
  17. 17journalRats, Communications, and Plague: Toward an Ecological HistoryMichael McCormick — 2003
  18. 18bookJustinian's Flea: Plague, Empire, and the Birth of EuropeWilliam Rosen — Viking Adult — 2007
  19. 19bookWales and the Britons 350–1064T. M. Charles-Edwards — Oxford University Press — 2013
  20. 20journalThe Justinianic plague: evidence from the dated Greek epitaphs of Byzantine Palestine and ArabiaNancy Benovitz — 2014
  21. 21journalBioarchaeological signatures during the Plague of Justinian (541–750 CE) in Jerash (ancient Gerasa), JordanKaren Hendrix et al. — 2026-02-01
  22. 22journalA Sixth-Century CE Drought in Arabia New Palaeoclimate Data and Some Historical ImplicationsJohn Haldon et al. — 2024
  23. 23webJustinian's Plague (541-542 CE)John Horgan — 26 December 2014
  24. 24webTwo of History's Deadliest Plagues Were Linked, With Implications for Another Outbreak2014-01-31
  25. 25webThe Justinianic Plague Origins2020-06-12
  26. 26journalThe Justinianic Plague and Global Pandemics: The Making of the Plague ConceptMerle Eisenberg et al. — December 2020
  27. 27journalThe Justinianic Plague: An inconsequential pandemic?Lee Mordechai et al. — 2019-12-17
  28. 28webAn Empire's EpidemicThomas Maugh
  29. 29journalThat earlier plagueJosiah C. Russell — Springer — 1968
  30. 31journalYersinia pestis DNA from Skeletal Remains from the 6th Century AD Reveals Insights into Justinianic PlagueMichaela Harbeck et al. — 2013
  31. 32journalYersinia pestis genome sequencing identifies patterns of global phylogenetic diversityGiovanna Morelli — October 31, 2010
  32. 33journalPlague as a Possible Factor for the Decline and Collapse of the Aksumite Empire: a New InterpretationGebre Selassie Yohannes — Mekelle University — 2011
  33. 34citationPlague and the End of Antiquity: The Pandemic of 541–750Peter Sarris — Cambridge University Press — 2007
  34. 35citationPlague and the End of Antiquity: The Pandemic of 541–750Michael McCormick — Cambridge University Press — 2007
  35. 36journalYersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysisDavid M. Wagner — April 2014
  36. 37journalEarly Divergent Strains of Yersinia pestis in Eurasia 5,000 Years AgoSimon Rasmussen — October 22, 2015
  37. 38newsBlack Death Genetic Code 'Built'Matt McGrath — BBC World Service — 12 October 2011
  38. 39journalA draft genome of Yersinia pestis from victims of the Black DeathKirsten Bos et al. — 12 October 2011
  39. 40journalRejecting Catastrophe: The Case of the Justinianic PlagueLee Mordechai et al. — Oxford University Press — August 1, 2019
  40. 41bookByzantium: The Empire of New RomeCyril A. Mango — 1980
  41. 42journalChallenging the Significance of the LALIA and the Justinianic Plague: A Reanalysis of the Archaeological RecordHaggai Olshanetsky et al. — 2024
  42. 43webRoman Plagues Struck During Cool, Dry PeriodsAmy Mayer — 28 February 2024
  43. 44journalClimate change, society, and pandemic disease in Roman Italy between 200 BCE and 600 CEKarin Zonneveld — 2024