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Questions about Yellow fever

Short answers, pulled from the story.

What is the size and genetic structure of the yellow fever virus?

The yellow fever virus measures 40 to 50 nanometers in width and carries a single-stranded RNA genome of approximately 10,862 nucleotides. This genetic material encodes a polyprotein that host proteases cut into three structural proteins and seven nonstructural proteins.

How does the Aedes aegypti mosquito transmit the yellow fever virus to humans?

A female Aedes aegypti mosquito transmits the virus by biting humans after ingesting blood from an infected person or primate. The virus replicates within the mosquito's stomach epithelial cells before traveling to the salivary glands for injection into human bloodstream during subsequent bites.

When do symptoms typically appear after infection with the yellow fever virus?

Symptoms typically appear three to six days after infection begins. Most cases result in mild fever, chills, loss of appetite, nausea, and muscle pain particularly in the back which usually improve within five days.

Where did the first definitive outbreak of yellow fever occur in the New World?

The first definitive outbreak in the New World occurred on Barbados island in 1647. Spanish colonists recorded an epidemic in the Yucatán Peninsula in 1648 where Mayan people called it xekik meaning blood vomit.

Who developed the 17D vaccine for yellow fever and when was it completed?

Max Theiler completed the creation of the 17D vaccine in 1937. He received the Nobel Prize in Physiology or Medicine for this achievement and protection begins by the 10th day after administration in 95% of people.

How many annual cases of yellow fever occur globally and where are they concentrated?

About 90 percent of an estimated 200,000 annual cases occur on the African continent. In 2016 a large outbreak originated in Angola and spread to neighboring countries before containment efforts succeeded.