When was Alzheimer's disease first recorded and by whom?
Alois Alzheimer examined Auguste D in 1901 and published his findings on her case that same year. This marked the first recorded instance of what would become known as Alzheimer's disease.
Questions about Alzheimer's disease
Short answers, pulled from the story.
What are the three stages of Alzheimer's disease progression?
The course of Alzheimer's disease generally follows three distinct stages: early or mild, middle or moderate, and late or severe. The final stage brings complete dependence on caregivers before death usually results from external factors like pneumonia rather than the disease itself.
Which genetic variant is the strongest risk factor for sporadic Alzheimer's disease?
The strongest genetic risk factor for sporadic Alzheimer's disease is the APOEε4 allele. Between 40% and 80% of patients possess at least one copy of this specific apolipoprotein E variant.
How can Alzheimer's disease be definitively diagnosed?
Alzheimer's disease can only be definitively diagnosed through autopsy findings examining brain tissue histologically for plaques and tangles. Clinical diagnoses remain possible or probable based on medical history, behavioral observations, and neuropsychological testing.
When was the blood test by Fujirebio Diagnostics approved for early detection of amyloid plaques?
In May 2025, the US FDA approved a blood test by Fujirebio Diagnostics' Lumipulse G device for early detection of amyloid plaques associated with AD in adults aged 55 years and older showing symptoms.